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This no effect boundary was chosen instead of the standard range (0.8, 1.25) based on the broad therapeutic range of liraglutide.
An equivalence approach with no-effect boundaries of 80 to 125% was used to assess bioequivalence.
Ratios of their pharmacokinetic parameters were close to unity and their respective 90% CIs fell within predefined no-effect boundaries of 0.8 and 1.25.
Ratio of the geometric mean values for Ca/Mg versus placebo were all close to unity and their 90% CIs all fell within predefined non-effect boundaries (0.8 to 1.25).
Ratios of geometric mean values of AUC0-t, Cmax, Cl, Vss and MRT for Ca/Mg versus placebo ranged from 0.95 to 1.06 and their respective 90% CIs fell within the predefined no-effect boundaries of 0.8 to 1.25.
If the 90% CIs for the geometric mean ratio fell within a no-effect boundary of between80%% and 125%, then it was to be concluded that there was no significant effect of Ca/Mg infusions on the pharmacokinetics of oxaliplatin.
These problem topics explain inherent limits lying at the heart of software, and in effect define boundaries beyond which computer science professionals cannot go beyond.
To take the boundary effect into consideration, boundary elements are also selected to produce data maps.
Due to the effect of boundary layer, the effective flow radius is less than the tube radius (Eq. 31).
To avoid edge effects, periodic boundary conditions were applied in all calculations.
The effect of boundary conditions is also examined.
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