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34 However, some studies have shown a neuroprotective effect (attributed to its high flavonoid content) 35 and an antioxidant action.
Primidone has also been shown to be effective in placebo controlled studies in ET (Koller and Royse 1986), with its anti-tremor effect attributed to its metabolite phenobarbitol (Sasso et al 1991).
However, animal studies have suggested it provides a more potent and longer-lasting hypouricemic effect compared with allopurinol, an effect attributed to its potent inhibition of both oxidized and reduced forms of xanthine oxidase [ 27].
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Previous studies have shown that acute intake of high-phenol virgin olive oil reduces pro-inflammatory, pro-oxidant and pro-thrombotic markers compared with low phenols virgin olive oil, but it still remains unclear whether effects attributed to its phenolic fraction are exerted at transcriptional level in vivo.
Despite the antioxidant health effects attributed to its consumption, there are no studies regarding the effects of the maná-cubiu on the MeHg toxicity in male reproductive system.
Past research on OA treatments reported a beneficial effect of large doses of bicarbonate on certain chronic joint diseases; the effect was attributed to its alkalinity [ 10].
The superior anticorrosion effect was attributed to its larger tortuosity of diffusion pathways, improved interfacial strength between the epoxy and filler, and the passivation layer formed by the presence of polyaniline which was confirmed by X-ray photoelectron spectroscopy.
PSK was previously reported to be effective in adjuvant immunotherapy for patients after curative resection of gastric cancer [ 25], and this effect was attributed to its immunomodulatory activity on NK cells [ 26].
Catechins' beneficial effects are attributed to its ability to reduce oxidative stress, lipid peroxidation, free radical generation and unhealthy low density lipoprotein (LDL) cholesterol-oxidation [ 36].
DAF-2 is a modulator of lifespan, whose effects are attributed to its role in regulating the FOXO transcription factor DAF-16.
Most of these effects were attributed to its estrogenic potential [ 6, 7]; however, also oxidative stress due to ZEN exposure has been identified as a cause of disturbance of fish cell functions [ 8].
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