Sentence examples for effect alteration from inspiring English sources

Changes in genes expression may create interpatient variation in drug effect, alteration in tumour microenvironment, and changes within cellular structures, metabolism and functions that promotes towards drug resistance.

A tight regulation of cAMP levels is required for female fertility; a decrease in cAMP (e.g., in Gprk2 mutants) leads to maternal effect alteration of embryonic anterior development, resulting in cuticle holes (Bellen and Kiger, 1988, Lannutti and Schneider, 2001, Schneider and Spradling, 1997).

Because cell cycle regulation is a key mechanism by which most chemotherapy agents exert their cytotoxic effect, alterations that may occur in cell cycle regulation in cancer may contribute to lack of response to some agents [ 4].

Thus, the combination of the two effects – alteration of Ca2+ influx and diminished capability of Ca2+ clearance by mitochondria – seriously increases the susceptibility of striatal cells expressing mutant HTT to excitotoxic insults.

"All agree," wrote one, "in the account of their sensations under its effects – alterations of cold and heat, fear and boldness, everything joyous and magnificent".

Toxic effects' alterations caused by system properties at population and community levels were discussed in particular, and the species-at-risk approach based on ecological traits was presented.

Such effect may be mediated through at least two effects: alterations in adipokine levels and increasing insulin resistance.

A third possibility is side effects: alterations that neither enhance the success of the oncogenic instruction nor protect the host from it (categories adapted from Ewald 1980).

Given that Tat protein regulates DAT function allosterically34,49, we tested whether mutated His547 attenuates the Tat effect through alteration to a conformational transporter transition.

Ch'ng Sl, Cheah SH, Husain R & Duncan MT (1989): Effect of alteration of eating pattern on serum frutosamine: total protein ratio and glucose level.

The effect of alteration in both substrate and protein structure is under investigation, with the goal of understanding the effect of changes in protein motion and active site geometry on tunneling.