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Medial necrosis was greater in PES struts in comparison to EES (Table 4, Figure 2).
The primary response of the RV to match increased afterload is increased contractility, which is defined as end-systolic elastance (Ees) (Table 2).
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Some of improved hits showed enantioselectivities in the range 80 90 % ee (Table 4).
Nevertheless, several large retrospective studies report a surprisingly high number of cases of KPEE among patients with EE (Table 1).
The best active catalyst in library A showing notably enhanced (S,S -selectivity turned out to be L114H/I116 V (80 % ee; Table 2).
In order to gain insight into the possible origin of the evolved stereoselectivity, substrate 1 was docked into homology models of the (S,S -selective mutant S,S -selective) and the (R,R)-selective mutant SZ502 (80 % ee) (Table 5).
This allowed enantioselective trifluoromethylation of aromatic aldehydes in up to 71% ee (Table 23).
Mutations have been identified in the hETHE1 gene of individuals with EE (Table 1) (6).
The LA Classification System was used to grade EE (Table 1) [ 15].
They used NFSI as fluorine source in MTBE, with high enantioselectivities (91 97% ee) (Table 10).
In contrast, reaction at the face afforded (S)- 2 with 48 % ee (Table 1, entry 10).
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