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The pooled analysis is also strengthened by the similarities between the EDITION studies in terms of design.
The EDITION studies were multicentre, randomized, open-label, parallel-group, phase IIIa studies, with similar designs and endpoints.
Severe hypoglycaemia was rare in both treatment groups in the pooled population of all three EDITION studies.
Similarities between study endpoints and study designs for the three EDITION studies have enabled a patient-level meta-analysis to be carried out.
The basal insulin dose in the Gla-300 group at 6 months was 12% greater than in the Gla-100 group, a finding that has been consistently observed in all three EDITION studies.
Methods were consistent with those of the EDITION studies and have been reported previously 3– 5. Change in HbA1c, and all other efficacy measures except insulin dose, was analysed using a mixed model for repeated measurements (MMRM).
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Particularly interesting is the case of the dragons' blood color wash, only present in the 20th century edition studied.
Since Woolf's pronouncement, countless editions, studies and adaptations of her novels have appeared.
The transition probability matrices are square with dimensions (N = 110), corresponding to the number of language editions studied.
Announced on August 17 and published on October 22, 1971, this four-volume, relatively expensive set became the "Senator Gravel Edition", which studies from Cornell University and the Annenberg Center for Communication have labeled as the most complete edition of the Pentagon Papers to be published.
Of the 2496 participants included in the pooled analysis of all three EDITION T2DM studies, 1247 were randomized to Gla-300 and 1249 were randomized to Gla-100.
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