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This confirms in part something I've suspected: that the marketing of popular cinema to different audiences (from the point of film producers) relies primarily on fleeting aspects of the industry like star power or popular themes, rather than the more permanent aspects of the moving image that a digital humanities approach can measure, like hue, saturation, editing patterns, or edge detection.
Recent studies indicated that editing levels can increase or decrease with a constant (or not significantly changed) protein expression of ADARs [39] [40], consistent with the opinion of Jacobs and colleagues that the differences in editing patterns may not be mediated solely by ADAR expression levels [41].
Here, we demonstrate the effect of temperature on RNA editing patterns using multiple known target RNAs.
Quality assurance results (12) highlighted the need for experienced judgment in evaluating and editing patterns and matching results.
For some genes, the actual RNA editing patterns from T. cruzi or, in the absence of the T. cruzi edited sequence, T. brucei were included for comparison.
Recently, Hassan et al. (2013) have reported that genetic differences between C57BL/6J and A/J at the Apobec1 gene affect global RNA editing patterns between these strains.
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Moreover, the connection between the differential expression of ADARs and an altered gene specific editing pattern was investigated for the first time to illustrate how the A to I RNA editing balance was deregulated in HCC.
Together, these results likely suggest that the differential expression of ADAR1 and ADAR2 in tumours, which is tightly associated with the altered gene specific editing pattern, may explain the A to I editing imbalance in HCC.
Additionally, most of the edits appeared in a bi-allelic manner, and the most abundant editing pattern was one base pair insertion at 3 bp downstream of the complementary NGG PAM site (Fig. 5h).
In addition, a different editing pattern was consistently found between Stratiotes and the rest of the Hydrocharitaceae (see below).
(B) The Ca-alpha1D (ca1D) transcript is edited at five sites, each of which displays a different editing pattern in response to temperature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com