Sentence examples for editing modification from inspiring English sources

Recent bioinformatics analysis has revealed that A-to-I editing modification occurs in at least 30 different organs with different frequencies and most editing events are found within Alu elements embedded in the non-coding regions of human transcriptome, which is suggested to be engaged in the modulation of tumor cell growth and differentiation [ 28- 32].

The expression levels of most miRNAs with altered isomiRs patterns were also significantly changed by TDP-43 knockdown, indicating a role of TDP-43 in miRNA editing, modification and/or turnover.

No alteration in the editing reaction was observed after celecoxib treatment, indicating that editing levels are extremely conserved and editing modifications may occur only after a longer treatment or in a situation of life-time inhibition of COX-2 activity as observed in COX-2−/− mice.

Therefore, in this study, we did not consider these RNA editing modifications.

Due to RNA bias editing, 5' modifications and 3' modifications, many pre-miRNAs produce multiple mature miRNA isoforms, namely isomiRNAs, as described in many studies [ 48– 50].

However, we note that the majority of the reported examples did not correspond to the typical C→U and A→I RNA-editing modifications.

Of all the VGSC subtypes found in mouse cochlear sensory epithelia, CbmNav1.5 was subjected to the most intensive RNA-editing modification, among which T-to-C and A-to-G were the two common nucleotide substitution patterns, containing six editing sites each.

But would we accept this kind of largely anonymous editing and modification in other mediums?

We also describe the most recent innovation of the CRISPR/Cas9 technology, particularly the broad applications of modified Cas9 variants, and discuss the potential of this system for targeted genome editing and modification for crop improvement.

The overarching concern appears to be that if legal content is made freely available for editing, use, modification and distribution, that the resulting content will be unreliable at best and just plain wrong at worst.

"I can envision various biomedical applications where the Cas9-CPs and ProCas9s will allow us to better understand disease processes and also enable safer translational applications of CRISPR-Cas genome editing and modification," the study's co-first author Christof Fellmann said in a statement.