Sentence examples for editing methodology from inspiring English sources

Although with different working modules, most of the genome-editing tools share the same editing methodology by introducing double stranded-breaks (DSBs) into a desired genomic site.

The prevalence of sequence errors among existing Ambystoma assemblies necessitated development of a quality-controlled manual editing methodology to minimize error rates within AESTdb contig sequences.

In this work, we provide proof of concept for a genome editing methodology that does not require homologous recombination by donor dependent repair and attains efficacies that are high enough to screen editing events by PCR using genomic DNA of a reasonable number of individuals.

This paper presents the procedures adopted to recover the Leixões sea level data from paper chart records as well as the data quality control and data editing methodologies.

Hence, the methodology we describe can be used as an alternative to existing genome editing methodologies to modulate almost all loci in the fly genome.

Hence, a strategy that does not require the need to test tools locus-by-locus would allow one to efficiently modify the locus of interest without the need for homologous recombination and without leaving exogenous sequences could serve as a parallel alternative to the current genome editing methodologies.

Together, RNA-guided Cas9 activity was able to generate indels with a relatively high frequency for all eight sgRNAs examined, demonstrating that the Cas9 genome-editing methodology is robust and efficient.

All eight sgRNAs examined in this study resulted in relatively high indel frequencies, demonstrating that the Cas9 system is a robust and efficient genome-editing methodology in CHO cells.

Then, by developing and optimizing a protocol of gene editing – a methodology that allows the introduction of specific changes in a cell's genome – the authors generate additional FUS-mutant iPSC lines that carry a severe mutation associated with juvenile ALS.

Both authors designed the survey methodology, edited the questionnaire instrument, and conducted the focus groups.

Judith Tintinalli, M.D., M.S. had primary responsibility for the study concept, developing methodology and editing the manuscript.