Sentence examples for editing factor from inspiring English sources
multiple organellar RNA editing factor.
Similar phenomena have been observed by Meyers and colleagues in a survey of SELEX-derived aptamers as compared to naturally occurring ones [11], as well as by Hallegger and colleagues, where SELEX was performed to detect RNA structural motifs with affinity to RNA editing factor ADAR, which binds dsRNAs, but no perfect double-stranded RNAs were sequenced from the resulting pool [17].
Such a factor could perform an additional function (or functions) unrelated to editing, and conserved bases could be important for such secondary function(s) of the editing factor.
Under this scenario, editing of nad3eU230SL and nad4eU272SL in the hybrid species P. eurystomum, P. collenchymatum and P. pyriforme might have become feasible by gain (from the parental P. sphaericum lineage) of the corresponding nuclear encoded editing factor PPR_56 (Pp1s208_104V6.1, [ 61]).
Such a loss-of-factor scenario would be consistent with several studies that demonstrated that transfer of editing sites from one species to another often leads to a failure to process the heterologous site, i.e. are indicative of a loss of the corresponding editing factor [ 4, 21, 40].
The gain of the editing requirement (i.e., a C instead of a T in the mitochondrial DNA) at one or both positions in the hybrid species can be explained by either maternal transmission of the organelle and thus transfer of the mutation from the P. sphaericum parental lineage, or by the independent gain of mutations (after loss of selection pressure by gain of the nuclear editing factor).
In addition, another group of small family proteins, multiple organellar RNA editing factors or RNA editing-interacting proteins (MORF/RIP), is required for plant organelle RNA editing (Bentolila et al. 2012, 2013; Takenaka et al. 2012, 2013, 2014).
In this study, we observed nearly full RNA editing at the D stem of trnM transcripts (52,826 position) in leaf, with significant (>29%) differential editing between leaf and floral tissues (Fig. 3; Additional file 1: Table S2), which suggested that tissue-specific tRNA editing factors might be involved.
Recently, PPR proteins have been identified as editing factors [ 13, 14].
This suggests possible multiple independent acquisition of the plant-type RNA editing factors in these two heterolobosean lineages.
Reduced editing can either be caused by the degeneration of nuclear-encoded editing factors or plastidial cis-elements that direct the editing machinery.
