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Distances between point locations, field boundaries, and shared Voronoi polygon edges were calculated using the ArcGIS 'Generate Near Table' tool.

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For an edge e from the node U whose lth iteration is scheduled at Fl + u time units to a node V whose lth iteration is scheduled at Fl + v time units in the original DFG with weight w e), with F as the folding factor, the new weight on the folded edge is calculated using the formula given in Equation 10.

The number and size of vinculin-positive focal adhesions at the wound edge was calculated using Slidebook software.

For each of the used jaguar observations, a circular buffer area representing a 29 km2 home range was simulated and the same landscape metrics from our spatial modelling (i.e. PLAND, mean patch size, patch density and edge density) were calculated using FRAGSTATS 4.2 (McGarigal et al. 2012).

The edge weights were calculated using the formula: (5) E ij = 1 B ij × N i × N j Where, Eij = edge weight between node i and j Bij = betweenness centrality of Eij Ni = node weight of node i Nj = node weight of node j Visualization of the network and calculation of betweenness centrality for each edge was done using Cytoscape [ 87].

Patch area, perimeter, and edge: area ratio were calculated using Hawth Analysis Tools for ArcGIS (freely available from www.spatialecology.com/htools) on polygons drawn around the patch boundaries using multi-band, high-resolution (4×4 m ground resolution) IKONOS imagery.

The upper photonic band edges of crystals A and B were calculated using Eq. 1as 1.3965 and 1.4382 eV, respectively.

Tree edge lengths for the given topology were calculated using the RAxML program under PROTGAMMALG evolution model (Stamatakis 2006).

Average measurements were calculated using the leading-edge technique of 3- to 5-consecutive sinus beats.

For each node, edge and resulting overall graph the available metrics were calculated using the scripts provided within the Brain Connectivity Toolbox [49].

All percentages were calculated using USD.

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