The cell migration cycle consists of several steps including protrusion of the leading edge, adhesion to the substratum, and release of the cell rear (reviewed in [1], [2], [3]).
Cell migration comprises several temporally and spatially coordinated events, including elongation of the leading edge, adhesion of this protrusion to the matrix, movement of the cell body and release of the trailing edge of the cell [ 14, 15].
It is of interest that regions in which adhesions assemble, e.g., nascent adhesions near the leading edge, growing adhesions, and translocating (treadmilling adhesions) adhesions all show relatively weak binding equilibria and low clustering.
The tires' breakaway at the ragged edge of adhesion was more progressive and predictable than the Mitsubishi's original-equipment Yokohama radials.
The moves on Hamilton and Bottas were made in his trademark style - making a hugely committed dive down the inside from a long way back, but always in total control on the edge of adhesion.
Most cars in this class feel a little wobbly near the edge of adhesion, as if the car is saying, "Whoa, fella, you're scaring me!" But the Mazda hangs on tight, with very little sway.
Cell migration involves a multistep process that requires formation of new adhesions at the leading edge while breaking adhesions at the trailing edge 16, 34– 36, a process that is mediated by its integrin receptors on the cell surface 10, 37– 42.
In contrast, adhesions in less motile cells are heterogeneous; smaller adhesions reside near the leading edge, and larger adhesions are more peripheral and at the rear of the cell (6).
It was determined that Fmn1-IV, as an actin nucleator, contributes to protrusion of the cell's leading edge and focal adhesion formation, thus contributing to cell motility.
Wild-type (WT) fibroblasts exhibit robust dynamic cell edge protrusion during adhesion to fibronectin-coated surfaces.
In the MGO-, Fand and CG-treated rats, fist-like round liver edge and extensive adhesion of the bowel and stomach were observed.
