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Such genomic heterogeneity both between and within individual tumours presents an economically intractable problem requiring a change in drug development strategic approaches.
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The only economically sound solution to the intractable health care mess is to simply pay high-quality, low-cost physicians more per service than we pay low-quality, high-cost-per-patient ones.
Market-based instruments (MBIs) are promoted as economically efficient, targeted solutions to otherwise intractable environmental policy problems with additional potential to improve the livelihood security of ecosystem service providers.
Unfortunately, corruption remained intractable.
It's intractable.
Difficult economically.
Damon is intractable.
But the alternatives look intractable.
Corruption remained an intractable problem.
He made intractable enemies.
Burdens are no longer intractable.
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