Sentence examples for ecm alterations from inspiring English sources
Experimental studies in rodents and baboons recapitulated ECM alterations and clearly linked ECM remodeling to apoptosis, inflammation, and altered growth factor signaling [85, 87 91].
LSM detected significant ECM alterations in all groups except sodium deoxycholate group with an almost completely preserved ECM.
These ECM alterations derived, at least partly from decreased SLRP levels and enhanced MMP activity within the myocardium.
Significant ECM alterations are observed in liver cirrhosis and fibrosis (Schuppan et al. 2001; Wells 2008a).
Hence, development of more cardiac-specific plasma biomarkers would provide more accurate insight into ECM alterations in the myocardium.
This analysis provided further validation that the Col2-Tgrdw transgenic mouse is a model of chondrodysplasia caused primarily by intracellular/ER stress without any major ECM alterations.
Surprisingly, few other immunohistochemical studies have been published on ECM alteration compared with clinical endpoints, whereas several studies have confirmed by transcriptomics that gene expression of various ECM proteins including collagens, tenascin, osteopontin, fibronectin, and genes involved in ECM regulation is upregulated in IPF [ 30- 32].
The phenotypic markers analysed in this context were MMP-1 and MMP-13, together with the v3 and v7/8 splice variants of CD44, which are instrumental in ECM alteration in malignancies and already known to be expressed in the synovial membranes of diseased joints.
The highly dynamic nature of the ECM causes several alterations during diseased conditions that result in the loss of cells specified for the desired function (Cattell et al. 1996).
The activation of HSCs and deposition of the ECM leads to alterations in liver microstructure that are reflected by an increase in the liver stiffness and changes in the blood flow.
Cleavage of proteins in the basal lamina by matrix metalloproteinases produced by invading inflammatory cells is required to facilitate their access to the CNS (63), thus alterations in ECM protein isoforms could alter blood brain barrier permeability.
