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Rabies is unique not only in terms of its invariably fatal course once disease signs develop, but it also has a variable incubation period (eclipse phase).
TOCC values decrease from 3 to 5 DU along with a reduction in UV radiation intensity from 20 to 35% from starting to the main eclipse phase.
We describe herein preliminary evidence that cellular miRNA may play a role in suppressing viral replication, explaining the eclipse phase, and that artificially designed multitargeting miRNA can successfully inhibit rabies virus transcription and replication in vitro.
Since the observed temperature variations at the orbital period range from 0.4 (^{circ })C during full sun phase to 1.7 (^{circ })C during eclipse phase, temperature variations cannot be avoided most of the time.
We find dominant wave periods range from 10 min to 1 h around the time of maximum eclipse phase which could be associated with atmospheric gravity waves excited due to the eclipse.
Similarly, a 6-km vertical wavelength in the meridional component shows an enhanced amplitude of ~2 m s−1 during the eclipse phase compared with ~1 m s−1 on the control day, whereas, after the maximum obscuration, the amplitude corresponding to a 6-km vertical wavelength becomes 2.5 m s−1 compared with 1.3 m s−1 on the control day.
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When the eclipse was total, I removed my special eclipse glasses — essential for viewing the eclipse phases safely — casually looked up at the sun, and staggered back a little, my brain reeling.
We found that the lunar surface temperature decreased by about 147 K and 220 K during the partial and total eclipse phases, respectively, in comparison with the lunar temperature before the eclipse.
Taken together, this information lends to the hypothesis that HMPV (and HRSV) lineages circulate in a cyclic trend of multiple eclipse phases preceding periodic population expansions.
Switching of the predominantly circulating subtype (HRSV) or genotype (HMPV) may be a result of fluctuating circulating frequencies of contemporary clades, which cycle through proliferative and eclipse phases, and is not due to novel lineage emergence events.
Sustained circulation of contemporary clades of both viruses for decades and their global dissemination demonstrated that switching of the predominant genetic group did not arise through the emergence of novel lineages each respiratory season, but through the fluctuating circulation frequencies of pre-existing lineages which undergo proliferative and eclipse phases.
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