The third ECG showed regression of the ECG modifications in Group A. In the women of Group B, the second and third ECGs were not substantially different, but there were statistically significant differences between the first and third ECGs.
ECG modifications are also rarely reported [53].
Electrocardiogram (ECG) modifications were defined as ST changes or T-wave inversion.
Uncertainty in the unknown and estimated parameters has possibly contributed to the mismatch between clinical observations and the predicted values yet the general conclusions on the drugs triggered ECG modifications can be made.
In addition, a stepwise logistic regression model revealed that NT-proBNP (OR = 1.01 per 100 ng/L, 95% CI 1.002 to 1.02), ECG modifications (OR = 11.03, 95% CI 5.19 to 23.41), and OSF score (OR = 1.63 per point, 95% CI 1.17 to 2.41) adequately predicted cardiac dysfunction.
In asymptomatic patients with no ECG or SA-ECG modification, the mean interval between the first and the second electrophysiological test tended to be longer than in other patients (101±34 months versus 81±29 months, NS).
In humans, the electrocardiogram (ECG) can undergo modifications in response to regular exercise that mimic changes associated with pro-arrhythmic states such as hypertrophic cardiomyopathy, e.g. [ 15, 21, 31, 32] although, the causes and outcomes of physiological and pathological remodelling are usually different, e.g. [ 10].
Only one patient without modification of ECG had a prolonged HV interval (sensitivity 80%, specificity 99%).
None of the patients showed signs of new or progressive cardiac disease, with stable ejection fractions and no modification on ECGs; none of the patients experienced renal crisis or symptoms suggesting progressive gastrointestinal disease.
The five patients with a HV interval of 70 ms or greater at the second electrophysiological test showed a modification in their resting ECG over time (n=4) or significant modifications in the SA-ECG (n=3) (table 3 and figure 2).
