Furthermore, 26.9% of EC asked for submission by e-mail or CD-ROM (number of copies ranging from 1 to 15) in addition to the paper version.
Three time milestones were considered for each application: the date of submission to EC, the date of EC opinion, and the date of signature of administrative agreement.
To settle the dispute over BAF, the Europe Commission (EC) called for the submission on the issue of surcharges.
So-called price reporting agencies calculate the benchmark rate using data provided to them by firms such as oil companies, banks and hedge funds, which trade oil on a daily basis – submissions which the EC suspects are in some cases fraudulent.
After all EC approvals were obtained, NRA submissions were made.
Every submission and communication with the ECs was handled in close collaboration with the sponsor study representative and the principal investigator.
Time to EC opinion was calculated as the interval from submission to the date of EC opinion either negative or positive, censoring at January 31st , 2010 cases with no EC opinion.
"Initial review" refers to the first submission of a protocol to the FTM-EC for review, whereas "continuing review" includes studies where the amendment of a protocol or continual annual approval has been requested.
Two evaluators (EC, RD) independently rated the reporting quality of manuscripts at initial submission and following peer review and revision, according to the MQAI.
Automated gene-calling and functional annotation (EC number, COG, Pfam, TIGRfam, KEGG, Metacyc) was carried out through submission of sequence assembly to Joint Genome Institute's Integrated Microbial Genomes Expert Review (IMG/ER) [ 34].
The impact of MD-CTA on time to EC opinion is displayed in figure 3; the top graph, including all submissions, suggests that time to EC opinion was shorter after (median 2.4 months) than before (median 4.1 months) MD-CTA.
