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This could be due to the presence of cell growth boosting factors in the T. arjuna bark extract and the high content of bioactive molecules such as polyphenols, terpenoids, reducing sugars, and other hydrophobic organic moieties which enable easy internalization of nanomaterials via hydrophobic interior of the cell membrane [40].
LPR is small in size (< 100 nm) for easy internalization.
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Although the NDs are too large to be used as systemic injections, the NDs are promising as a sustained local drug delivery system for the treatment of tumor for their easier internalization and high cytotoxicity to the cancer cells.
I do not think one can neglect that it is easier to conceive that difficulties of a transitory internalization are easier to surmount than a permanent internalization.
Although strong intracellular expression of MOR-mcherry hampers easy detection of receptor trafficking, internalization was detectable in primary hippocampal neurons from MOR-mcherry mice upon DAMGO exposure (Fig. 2c).
AMNPs have advantages of easy and rapid absorption and subsequent internalization by endocytosis [ 50, 54, 55].
Internalization has been shown for NMDAR antibodies in live neurons in culture (Dalmau et al., 2008; Hughes et al., 2010), but obtaining cultured inhibitory neurons in sufficient numbers for quantitative analysis of internalization of GlyRs is not easy.
Salmonella isolates from internalized condition showed considerable internalization potential.
Also, the firms' controls over the entire supply chains facilitated their internationalization based on the Internalization advantage of OLI model; managing overall system makes it easy to transfer organizational assets across the international operations within the organization fast and consistently (Zhao & Decker 2004), like a franchise retail store format.
The economist Joseph Farrell called this the "internalization of complementary efficiencies".
"There is plenty of evidence of the benefits to investors from internalization," Ms. Inel said.
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