To overcome the obstacles of easy dissolution of PVA nanofibers without crosslinking treatment and the poor electrospinnability of the PVA cross-linked nanofibers via electrospinning process, the PVA based electrospun hydrogel nanofibers are prepared with post-crosslinking method.
Low polymer and crosslinker concentrations are required in order to have easy dissolution in water and in the water/cosolvent mixtures.
Noble metals (e.g. Ag, Au, and Pt) also have some drawbacks, including rarity, high cost, and easy dissolution (especially for Ag) upon exposure to air or humidity.
Therefore, the water content must be reduced to permit firstly an easy dissolution of the polysaccharide in the IL and then to avoid the hydrolysis of the EPS by sulfuric acid formed when the sulfating agent SO3·Py is added to the reaction medium [ 35].
Washing at higher temperature (140 °C for DMF and 90 °C for DI water) led to greater reductions in thickness due to easier dissolution of PVP at higher temperature.
Notably, the observed longer gap length in the S2 devices was attributed to either easier dissolution of the Cu filament or higher amount of electron injection from the Cu electrode through the Ti nanolayer.
The longer gap length of the S2 devices produced a higher resistance ratio (approximately 104 vs. 10, respectively) than that exhibited by the S1 devices because of the easier dissolution of the Cu filament through the defective TaOx solid-electrolyte.
The enhanced spheroidization behavior of the present pearlite phase was discussed in terms of easy carbon dissolution from cementite into pearlitic ferrite due to intensive plastic deformation of cementite.
Increasing the drug concentration from 25 mg to 50 mg (E4), it was expected that matrix of gel formed becomes more relaxed allowing easy penetration of dissolution fluid leading to enhanced drug diffusion; however, no significant (P < 0.05) influence over drug release was observed.
The contact angle study can be used as an easy method to determine the dissolution mechanism of amorphous solid dispersions through fitting the profile of contact angle of water on a series of tablets.
But determining the rate of dissolution is no easy feat.
