The other is faster and easier identification of clonal cell lines that show stable, high level production as candidates for large scale manufacture of protein therapeutics.
Even so, this technique still does not allow easy differentiation of small clonal populations from within a polyclonal primary sample.
We revised the manuscript to make the clonal experiments easier to follow and analyze in detail, as requested.
This allowed an easy and clear distinction of clonal complex-specific variants of these genes.
Because Drosophila has fewer mitotic cells and a simpler tissue architecture, it affords easy detection and analysis of early clonal tumor growth.
SRST output is compatible with common analysis tools such as eBURST, Clonal Frame or PhyloViz, allowing easy comparison between novel genome data and MLST data.
Both the Cebula and Guard-Bouldin laboratories have shown that, especially with clonal pathogens, it can be easier, more efficient, and more productive to go from phenotype back to genotype, instead of starting with genomic analyses.
When input reads are all sourced from highly inbred individuals (e.g., from clonal lines of Drosophila), this is easy to ensure: any variation should result from sequencing error, and the popular "majority vote" mechanism will create a correct consensus [ 1].
Easy accessibility and handling, in combination with elegant experimental techniques like clonal assays [ 2, 3] made the hematopoietic system the best studied mammalian stem cell system.
PCR is a rapid and easy technique that can detect the abnormal rearrangement of the bcl-2 gene and clonal IgH rearrangement, indicating the presence of lymphoma.
One way to broaden clonal selection could be by the induction of somaclonal variations which ranged from easy to detect deviations in general morphological characteristics to subtle deviations in e.g., vigour, bunch and berry sizes, sugar and acid concentrations, and flavour components.
