Chaotropic unfolding of heme-HSA in the F, N, and B conformations is governed by different thermodynamic regimes, with the B form showing an entropic stabilization of the structure that compensates an enthalpic destabilization, and the F form easily unfolding under entropic control.
This partial unfolding appears to be one of the factors associated with the accumulation of ubiquitinated proteins in neurodegenerative diseases; highly aggregated proteins are poor proteasomal substrates as they cannot be easily unfolded.
Although her latest work, "Ruined" (at the Manhattan Theatre Club, under the direction of Kate Whoriskey), is set in the present-day civil-war-torn Democratic Republic of the Congo, its drama could just as easily have unfolded amid the gang wars of South Central Los Angeles.
That said, these dishes from the Spanish playbook -- including paprika shrimp, cauliflower fritters, serrano with persimmons, and chorizo with sherry -- unfold easily.
The "Works with Cardboard" device easily lets you unfold the cigarette case-sized viewer and pop in any smartphone to view 360 content anywhere you are.
Packing away parachutes in a form that is compact yet guaranteed to unfold easily and reliably is obviously useful; but there is also a growing demand for sheet-like structures on spacecraft, such as solar panels, telescope mirrors, thermal shields and solar sails.
The biological relevance of these studies is with respect to the dynamics of channels: their requirement of flexibility for ion channel activity means that they must not unfold easily when subjected to conformational stress.
These data gave rise to a new theory of the DNA organization: the fractal globule, that is, a crumpled, knot-free polymer conformation of about 1 μm in diameter with a FD of nearly 3, which enables maximally dense packing, but maintains the ability to easily fold and unfold any genomic locus.
"We're finding these plates unfold fairly easily, and they're not that deformed," Suppe says.
