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Compared with unmodified micelles, RVG-modified micelles can be more easily internalized by the neuro2a cells and efficiently silence gene expression.
5 The term "bioavailability" refers to "the extent to which the lead is in a form which is easily internalized by the body, i.e., the extent to which it is in a form which can be physiologically transported through the lungs, gastrointestinal tract, skin, etc. and absorbed into the bloodstream.... .. R.R. at 313a-314a.
Previous reports [ 10, 12, 14] have shown that NPs with small diameter and large surface area/volume ratio induce higher cytotoxicity in comparison with the larger NPs, probably because they were easily internalized by the cells, and, at the same weight/volume of the medium, they were also administered in larger number.
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The progress of the technique in vivo relies primarily on the choice of cell labels that are easily internalized by cells and can be readily visualized by MRI.
MPIOs can be easily internalized by several types of cells and allow for labeling capacity up to hundreds of picograms of iron per cell without affecting cellular viability [ 35].
Preliminary results indicated that the wormlike brushes could be internalized by the cells easily, suggesting the potential application as advanced vehicles for delivery.
S-Lauroylglutathione (lauroyl-SG) and S-palmitoleoylglutathione (palmitoleoyl-SG) were easily internalized into the cells and they significantly reduced Aβ42-induced oxidative stress in human neurotypic SH-SY5Y cells.
However, the macrophages cannot be easily identified because ultrasound backscattering from macrophages is similar to that of the background tissue, and the nanoparticles internalized by the cells do not provide significant contrast in ultrasound images.
Therefore the conscious mind, by itself, cannot unravel what has already been internalized by the unconscious.
At that point, large packets of virus are simultaneously released by the infected cell and internalized by the recipient cell.
The DOX-loaded micelles could be internalized by the cancer cells efficiently, resulting in the effective inhibition to cancer cell proliferation.
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