Two calix[4]arene thiourea derivative 2 and 3 have been prepared by the reaction of the easily accessible 1,3-distally substituted calix[4]arene amine 1 with the corresponding isothiocyanate in dry CH2Cl2 with satisfactory yield.
In order to verify whether adipose-derived stromal cells (ASC) represent an easily accessible cell type that may substitute for BMSC completely in cell-based approaches for osteochondral regeneration, they were characterised in terms of in vitro performance (Refs 9, 10), in vivo localisation (Refs 11, 12) and their ability to differentiate into various mesenchymal cell types (Refs 13, 14, 15, 16).
Given the difficulty in obtaining tissue from typical bone metastases in prostate cancer, more easily accessible prostate lesions might offer a substitute for identifying genetic derangements leading to primary resistance of metastatic disease.
The use of I-MIBG (the best reported imaging modality for cardiac sympathetic denervation) is highly reproducible and is an easily accessible method, making it not readily substituted by other modalities.
"For consumers, you have to market them very persuasively to get them to spend, like, 10 bucks out of their pocket because they have so many substitutes that are free and easily accessible," Jang says.
This amounts to an electronic substitute for a textbook, but more easily accessible, comprehensive, relevant and user-friendly.
The single, easily accessible cell source and streamlined, bioreactor-based process makes the approach attractive towards manufacturing of clinically relevant sized bone substitute grafts.
The epidermis is a self-renewing tissue that is easily accessible and can provide large numbers of autologous cells that can be used for generating insulin-secreting skin substitutes.
Public transportation is easily accessible.
This technology is routine and easily accessible.
Mount Rushmore is easily accessible by road.
