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This is consistent with other studies that suggest dinucleotide repeats are generally more variable than other motif lengths, most likely due to the relative ease of mutation via DNA slippage during replication (Levinson and Gutman, 1987; Grist et al., 1993; Strand et al., 1993; Tautz and Schlötterer, 1994; Chakraborty et al., 1997; Sup Lee et al., 1999; Ellegren, 2000, 2004).
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As mentioned above, the ease of identifying mutations in SB-induced tumors through amplification of transposon/genome junctions is a major advantage of the system.
In genetic screens, the type of mutagen (e.g. ENU, x-ray, insertional mutagen) will determine the range of possible genetic mutations and phenotypes, as well as the ease of identifying the mutation [ 2, 10].
Given the diagnostic and prognostic importance as well as the robustness and relative ease of IDH1 and IDH2 mutation testing, it is very likely that determination of these mutations will soon become a part of the routine diagnostic assessment of gliomas.
These search features simplify accessibility to the database entries and ease of finding of a particular mutation.
For ease of testing, both genotype (HFE mutation analysis) and phenotype (ferritin and TS) should be performed simultaneously at a single visit.
In this context, microsatellites, or simple sequence repeats (SSRs) are commonly used, as they have a number of desirable features, such as ease of use, codominance and high mutation rates [ 2].
Figure 5 compares the cross-validation performance (MCC) of EASE-AA2, EASE-ASA, EASE-SS, and EASE-MM for different types of mutations.
A panel of 400 hotspots delineated in the TCGA dataset is highlighted for ease of interpretation the 400 most frequent mutations in TCGA cover 55.49% of Broad patients.
The relative ease of capturing and maintaining lethal mutations makes balancer systems the method of choice for essential gene studies.
C. elegans presents an excellent genetic model due to the ease of capturing and maintaining specific mutations using specialized chromosomes known as genetic balancers (Jones et al. 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com