Sentence examples for early upstream from inspiring English sources

Here, transdisciplinary Foresight, as a setting for early upstream engagement in strategy and policy programme development, offers resolve.

These results suggested that an increases in [Ca2+]cyt was also an early upstream event in the signaling pathway leading to O3-induced cell death in A. thaliana cells, and also suggested the involvement of the anion current increase in this signaling pathway.

Mitochondrial fragmentation seems to be an early, upstream event in mitochondrial dysfunction in the hepatotoxicity of Cd.

The early termination of fiber elongation in the Li 1 mutant is likely controlled by an early upstream regulatory factor resulting in the altered regulation of hundreds of downstream genes.

The step of signal initiation is considered to represent the early events that occur upon receptor engagement, and this early upstream process regulates the downstream targets both qualitatively and quantitatively.

Three case studies were presented at the workshop that described available data on toxicologic pathways connecting chemical exposures to early upstream biological events and then to subsequent overt effects, which are considered "downstream": a) thyroid hormone disruption and related toxicities; b) antiandrogen-mediated male reproductive effects; and c) upstream indicators of immunosuppression.

These transcription factors act as a point of convergence for earlier, upstream pathways and act combinatorially with each other, as well as with cardiac-specific and ubiquitous transcription factors to target the expression of genes involved in later events in cardiac development (Olson, 2006).

Furthermore, the finding that Wit did not inhibit EGF-stimulated EGFR tyrosine cross-phosphorylation indicates that Wit does not inhibit earlier upstream steps of growth factor receptor activation such as EGF binding to its receptor or the tyrosine kinase activity of EGFR.

Future investigations should focus on early events upstream from NF-κB and stress kinase pathway activation, as well as clinical studies to determine the utility of CO-based therapies in the management of acute inflammation.

In conclusion, our results identify a novel role of PP2A on regulation of chondrocyte proliferation, that intervenes early and upstream of p107 dephosphorylation to mediate FGF-induced growth arrest.

These genes might represent prime candidates for the identification of early and upstream regulators of the incompatibility response.