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We have occasionally observed clay particles in water collected by the needle-sampler and have attributed their presence to migration of groundwater below the bottom of the hole or to an early trigger of the sampler.
A previous report indicated that HMGB-1 was a late mediator of endotoxin-induced ALI and an early trigger of inflammation in animal models via RAGE activation [ 27].
It is interesting to note, that overexpression of S100A8 and S100A9 was observed in neurons of Kras mutant mice model acting as an early trigger of gliosis.
Translocation of gut microbiota, particularly endotoxins or lipopolysaccharides (LPSs) on the surface of gram-negative bacteria to the systemic circulation, has been proposed to be an early trigger of inflammation and obesity (8).
As intracellular Ca2+ increase is one of the earliest events following neuronal activation during learning, our results suggest Ca2+ could be an early trigger of the cellular cascades leading to de novo gene expression-dependent LTM formation.
High mobility group box nuclear protein 1 (HMGB1) is a DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like-receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).
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This creates acute laminitis, and we can see the early triggers of the disease; the changes as a result of the onset of the disease.
To expand our knowledge of the early triggers of NEC we describe our efforts to investigate NEC pathogenesis at an early stage of disease.
Based on its rapid appearance, we suggest that SNAIL1 expression is one of the early triggers of Type II EMT.
We observed a clear tendency toward early triggering of apoptosis only in cells overexpressing the mutated form P86L‐CALHM1 at 3 and 6 h (data not shown).
The serum stiffening effect was rather rapid (<1 h), compatible with a role in the early triggering of leukocyte sequestration in the microvasculature.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com