Sentence examples for early steps of transformation from inspiring English sources

The results show that EMT can be activated as a coordinated gene expression program in association with early steps of transformation.

An altered microenvironment may even rupture the homeostasis and favour the early steps of transformation (Raaijmakers et al, 2010).

We then focused particularly on genes involved in the regulation of the cytoskeleton, one of the processes occurring during carcinogenesis and in the early steps of neoplastic transformation.

These data suggest that concomitant DNA methylation of the RASSF1A and SFRP1 (exon 1) genes may play a role in the early steps of mammary transformation.

The objectives were to identify changes in gene expression occurring in the early steps of cell transformation as well as pathway disturbances that may trigger a carcinogenic process.

These findings are in agreement with previous reports sustaining that the hypermethylation of these genes is a cancer-specific event in gastrointestinal carcinogenesis since the early steps of neoplastic transformation [ 9, 44– 44].

The function of the CRBP-1 gene in controlling the cell bioavailability of vitamin A suggests that it can have a special relevance in the inhibition of early steps of cancer transformation.

As an evidence of how important epigenetic alterations are during the early steps of malignant transformation, a recent study showed that murine melanocyte cells that are resistant to apoptosis induction by adhesion blockade (anoikis-resistant cells) could be selected when cultured in agarose-coated plates.

Facing TRAIL challenge, cancer cells may need to develop strategies to survive and proliferate in vivo by acquiring resistance to this cytokine at early steps of the neoplastic transformation.

We observed that there was decreased expression of TGFβ2 and TGFβR2 (2.4- and 3.5-fold respectively) in Cr VI) transformed cells, suggesting that the loss of a cell response to TGFβ induced growth inhibition might be an early step of cellular transformation and tumorigenesis.

For example, during cell division in the early steps of embryonic development [ 10, 11], or during cellular transformation and cancer development [ 12], and as well, in stress conditions and apoptosis [ 13].