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TNF-α participates in early steps of inflammation, causes aggregation of inflammatory cells and plays important roles in inducting expression of other inflammatory cytokines[34].
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As extracellular ATP is degraded in adenosine within minutes, it is more likely that adenosine participates in early steps of NLRP3 inflammation activation rather than in sustained inflammasome activation, as suggested recently.
The aim of this study was to identify genes implicated in the early steps of the autoimmune process, prior to inflammation, in T1D.
This effect is evident during early steps of VSV replication.
(A ) Early steps of PIC assembly.
This could be especially relevant during early steps of tumorigenesis.
This discrepancy to the DKO* model might be due to the fact that Imiquimod induces only an acute and transient skin inflammation, thus mimicking only very early steps in psoriasis inflammation.
The critical steps of inflammation are summarized in Fig. 2.
Because adhesion is one of the earliest steps in inflammation and atherosclerosis, leading to the subsequent migration of blood leucocytes into the sub-endothelial space, the decrease in the adhesive properties of activated endothelial cells may be an important mechanism by which A. Melanocarpa fruit exerts its anti-inflammatory and anti-atherogenic effects.
The migration of circulating leukocytes to injury sites is an early step in the inflammation process and involves a sequence of coordinated interactions between leukocytes and endothelial cells (Luster et al., 2005; Langer and Chavakis, 2009).
Given that astrocyte injury is thought of as an important early step in brain inflammation and GFAP is implicated in astrocytic functional processes [ 6], these findings support the hypothesis that citrullination is important in the pathogenesis of this demyelinating disease.
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