Sentence examples for early steps of breast from inspiring English sources
Several miRNAs have been implicated in the regulation of early steps of breast cancer metastasis (reviewed in [47]).
Thus, loss of PERK signaling might influence downstream genetic and/or epigenetic changes favoring hyper-proliferative disorders characteristic of early steps of breast cancer progression.
In this study, we derived a unique invasion gene signature that we expect will reveal important information about novel mediators of the early steps of breast cancer metastasis: migration and invasion in the primary tumor.
Data from the present study may help in the development of more efficient therapeutic approaches in breast cancer, addressing the need to target simultaneously multiple molecules that are relevant to this early step of breast cancer progression.
Here, we used a 3D-co-culture system to mimic an early step of trespassing breast cancer cells through the lymphatic vasculature.
The present findings suggest novel mediators specifically for the early steps of metastasis, invasion, and hematogenous dissemination of breast tumors in vivo.
From a recent screening of an RNA interference library in cells defective in the early steps of metastasis (migration and invasion), KLF17 was identified as a metastasis suppressor in human breast cancer.
Because migration and invasion are the early steps of metastatic progression, the novel markers that we identified here might become valuable prognostic tools or therapeutic targets in breast cancer.
(A ) Early steps of PIC assembly.
This could be especially relevant during early steps of tumorigenesis.
