Sentence examples for early steps of brain from inspiring English sources
In the same line, the VE-cadherin/CCM1 (a protein encoded by the CCM1 gene which is mutated in a large proportion of patients affected by cerebral cavernous malformation) complex controls aPKC-ζ activation and Par-3 localization during early steps of brain endothelial cell polarization [ 98].
We thank Dr. Raya Eilam for help in the early steps of this investigation with injections into the brains of newborn mice, brain slicing and staining, Prof. Menahem Segal for his comments and advice, Ms. Danielle Sabah-Israel and Ms. Adi Lea Sela for their editorial assistance and Mr. Ishai Sher for graphical assistance.
In this study, we show a novel function for NDE1, whose mutations cause brain developmental disorders, in safeguarding the genome through S phase during early steps of neural progenitor fate restrictive differentiation.
(A ) Early steps of PIC assembly.
This could be especially relevant during early steps of tumorigenesis.
Likely, from the earliest steps of vertebrate evolution two main alternative functions were divided between the hemispheres: the left brain predominantly controls the behavior in routine situations, while the right brain specializes in responding to unpredictable changes in the environment [7].
Given that astrocyte injury is thought of as an important early step in brain inflammation and GFAP is implicated in astrocytic functional processes [ 6], these findings support the hypothesis that citrullination is important in the pathogenesis of this demyelinating disease.
Implications and future directions This study shows that the zebrafish– M. marinum model is particularly suitable for characterization of the early steps in the formation of brain granulomas, their immunological composition and the effect of bacterial virulence factors in the context of TBM.
Early identification of brain damages can lead to major changes in therapy such as the use of anticoagulants.
