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On the contrary, other reports in OSCC showed its expression was associated with a better prognosis based on the finding that S100A7 is highly expressed in pre-invasive, well-differentiated and early staged OSCC, but little or no expression was found in poorly differentiated, later-staged invasive tumors [ 23].
With a suspicion of an early staged pancreatic cancer, the patient underwent distal pancreatectomy and splenectomy with lymph node dissection (D2).
Overall, our data showed rather marginal tumor responses to pyrvinium treatment (see Table S3, Figure 6A and 6B), with some responses seen in HCT116 colon cancer and A2780 ovarian cancer (early staged tumors) models, but little in PC3 prostate cancer, AsPC1 pancreatic cancer, and A549 NSCL tumor models.
However, there is still no ideal resulotion for the early staged osteonecrosis.
PIN1 was diffusely expressed in the root meristemoids and early staged ARPs (Fig. 6P).
Many patients develop local recurrence and distant metastasis even following resection for early staged disease [ 3, 4].
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