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As seen in these results, Ccl2, Chka, Thrb and Synj2 are examples of sensitive genomic responses to chronic PCB126 exposure, however, they do not exhibit the early subchronic responsiveness that would make them beneficial as biomarkers in early stage identification of PCB126 exposure.
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In addition to virtual screening supporting the early-stage identification of lead compounds, inverse virtual screening is another cost-reduction strategy, in which a single drug is evaluated against many proteins in order to identify its putative off-targets [19, 20].
In conclusion, our key finding concerning the dependence of the efficiency of interventions on the pandemic profile demonstrates the critical importance of developing tools for early-stage identification of the pandemic profile in order to adapt the public health response in as timely a manner as possible.
We choose to study the early events after ureteral ligature because in early stages the identification of cell types and their putative phenotypical changes might be better traceable than in advanced stages of fibrosis.
Due to the glaucomatous optic nerve damage and visual field loss often are asymptomatic in the early stages, the identification of individuals with glaucoma at the earliest possible time is important to prevent a calamitous loss in vision [ 1].
Previous research has demonstrated the value and importance of artefacts and how they are handled by the CMP scientists, especially at this early stage of the identification process (Moyssi et al. 2016).
In early stage disease especially identification and sampling of the tumour within the prostate gland can be highly challenging.
Although this early stage screening allowed identification of neuroprotective compounds, further validation of hits from this assay will be necessary in higher vertebrate models of ALS.
A very high percentage of families in the UK are registered with a general practice so identifiable risk factors in routine primary care data could allow access to interventions at a much earlier stage than identification via contact with social care services.
Screening programs for the identification of early stage CRC and pre-neoplastic conditions can significantly improve disease outcome because of the treatment benefit of early detection [1].
Metabolomics may provide biomarkers useful for identification of early stage diseases, potentially addressing an important clinical need.
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