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They catalyze their own splicing, which suggests an early role for RNA in life or even in life's origins.
I'm referring to Tony Soprano and Breaking Bad's Walter White: on Seinfeld, Elaine had an on-off affair with Tim Whatley, the dentist who converts to Judaism for the jokes, which provided an early role for Bryan Cranston.
It was the first film role, as a new kind of anti-authority anti-hero, for the scrawny young Courtenay, gave an early role for James Bolam and provided glimpses of James Fox, John Thaw and Frank Finlay.
Director Sinclair Hill saw how well the improvised lines of the child actors (an early role for future director Jack Clayton and his sister) went over and also allowed the rest of the cast to "gag" or ad lib.
Later that decade, George Plimpton featured as a God who advises a fired ad man to start up his own business, only for him to go forth and found a religion predicated on selfishness, in A Fool and His Money (1988), a film now notable only for providing an early role for Sandra Bullock, as the ad man's girlfriend.
Iridescence in the feathers of a feathered dinosaur suggests an early role for feathers in ornamental display and signaling.
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Ashton's early roles for Fonteyn show her as a sensual being: the seductive Creole girl in Rio Grande, Tiresias the sexual experimenter.
A current accepted model for pre-TCR and TCR signal transduction during T cell development, as well as for TCR-mediated activation of mature T cells, involves critical early roles for Lck, ZAP-70, LAT, and SLP-76, which in turn transduce signals to downstream molecules including PLC -γ1, Vav, and ERKs[1], [2].
These results suggest that there is a likely role for Kif3B in the GRP, but that there are other early roles for Kif3B that are distinct from ciliary flow.
The EE/IE score for Pab1 is lower than that of Mex67 and similar to that of Nab2, supporting early roles for both Nab2 and Pab1 in the nucleus.
The presence of a large number of Msh4- Msh5 foci in zygotene supports early roles for Msh4- Msh5 in meiosis, perhaps during initial interhomolog interactions (Storlazzi et al. 2010).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com