As a consequence of this slower proliferation, these tumours respond in a similar manner to late-responding normal tissue rather than early responding normal tissue [13 15], thereby removing the rationale for hyperfractionated schedules.
As the dose per fraction increases, the probability of toxic effects in late-responding normal tissues increases disproportionately compared with early responding normal tissues, which are typically less sensitive to fractionation [4].
The most heavily exposed groups included occupants of buildings, passersby, residents of lower Manhattan, and early responding rescue/recovery workers.
The results indicate a possibility to use RBP as an early responding marker of late renal impairment after 177Lu-octreotate treatment in humans.
Since primary GR target genes should show GR binding to their TSS regions (either directly or via looping from distal regulatory elements), we tested all early responding nuclear receptor genes and the TSC22D3 reference gene.
In order to investigate, whether GR association was observed with the regulatory regions of early responding genes also in the human system, we performed ChIP assays with extracts from undifferentiated SGBS cells using anti-GR antibody (Fig. 4).
