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"We intentionally focused on this early phase of passionate love.
I absolutely love the early phase of a start-up.
The feared phase of escalation began.
The data are also comparable to those seen in an earlier phase I dose-escalation, monotherapy study of regorafenib in 53 patients with treatment-refractory advanced solid tumours, where a disease control rate of 66% was reported [ 48].
Both are in the early, intense phase of treatment.
The initial dose escalation phase of the study consisted of four cohorts.
Thirteen patients were treated in the dose escalation phase of the study and treated with a single laser fibre.
No DLTs were seen at the 30, 50 and 70 mg dose levels during the escalation phase of the trial.
4. Regular institutional review of antimicrobial stewardship, with early de-escalation of broad-spectrum antibiotics wherever possible.
It is made up of two phases: a dose escalation phase with 15 patients and an extended pivotal phase with an additional 55 patients.
Testing preload dependence may also be helpful in the de-escalation phase of shock management.
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