These abnormalities, alone or in combination, may contribute to the earlier onset, advanced stage, more aggressive histologic features, and worse survival of the breast cancers.
TOP2A over-expression seems to be correlating with the aggressiveness of HCC in terms of early age onset, advanced histological grading, microvascular invasion, chemoresistence, tumor recurrence and mortality [ 29, 30].
In October 1941, he rejoined the 35th Infantry Division at Dnepropetrovsk, Ukraine, where the German advance had halted because of the early onset of winter.
In diseases such as breast or ovarian cancer, the incidence of which increases with advancing age, the 'mere' acceleration of disease progression could contribute to the early onset of disease that is characteristically seen in carriers of BRCA mutations.
Dillis has early onset dementia.
Premature menopause is defined as onset before 40, while early onset menopause occurs before 45.
Some diseases, like early onset Alzheimer's and early onset heart disease, are more linked to family histories than others, like most cancers and Parkinson's disease.
Looking back, he realizes that he suffered from early onset idiotism.
Tragically, singer John Mann was diagnosed with early onset of Alzheimer's disease last September.
