Sentence examples for early mutations from inspiring English sources

Furthermore, albeit with small numbers of informative early mutations, the mutator phenotype was not evident before the occurrence of trisomy 1q.

In some cases, high ranking clonal CIS loci demonstrate weak selection between early mutations and late-stage clonal mutations (e.g. Bzrap, Rreb1), suggesting these are more likely to be passenger mutations resulting from integration site biases of MuLV.

Including these subclonal mutations in the analyses, i.e., comparing all late-stage integrations to early mutations, reveals some CIS loci with selection that is more significant than in clonal analysis alone (Supplementary Data 2), including verified human cancer genes such as REL, EBF1, ERG, ELF4, MYCL, KIT, and KDR.

First, in a collection of such deep samples, the star phylogeny is not expected to hold exactly, because preservation of early mutations is likely to occur stochastically at a low frequency.

Furthermore, a substantial number of early mutations in HIV are reversions of viral adaptations to non-adapted or wildtype virus in the absence of the selecting immune pressure [14] suggesting a fast rate of forward and reverse mutations relative to HCV.

Early mutations are promising therapeutic targets, and late mutations are important in metastasis.

Early mutation detection may aid in risk stratification and molecular-based treatment decisions.

We wish to find the distribution of the total number of mutants, including descendants of early mutation events.

Fourth, an early mutation might confer the potential to metastasize, but that potential may only be activated by a later mutation [2].

As a hypothetical model, the molecular pathogenesis of AML requires cooperating mutations of several genes such as early mutation, class-I and class-II mutations.

A number of early mutation studies did not perform expression analysis and relied solely on the ASSEDA or ASSA server to interpret potential mutations.