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Fibrin deposition and hyaline membrane formation are considered important early features in diffuse alveolar damage, the hallmark of ARDS [1, 10 12].
In addition, the role of oxidative stress has been evaluated in experimental models of acute pancreatitis [43] and it should be emphasized that oxidative stress and excessive ROS generation are early features in AP and consequently a difficult target for clinical prophylaxis to prevent a severe course of the disease.
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For example, atrophy in the hippocampal formation is an early feature in the progression of Alzheimer disease, with patients demonstrating impairments in spatial orientation and navigation.
Prof Tony Charman, Centre for Research in Autism and Education at the Institute of Education, said: "Differences in the use of eye gaze to regulate social interaction are already a well-recognised early feature in many children with autism from the second year of life.
Our hypothesis was that increased postprandial NEFA appearance and oxidation may be an early feature in non-diabetic subjects at high risk of developing T2D.
We hypothesized that miR-155 up-regulation may be an early feature in gba1 −/−.
Endothelial dysfunction is an early feature in the development of vascular complications in people with diabetes [ 1].
This hypothesis has been supported by studies demonstrating a cortical hyperexcitability in ALS patients, which seemed to be an early feature in both FALS and SALS [ 25, 26].
Expression of MHC class I on the surface of muscle cells is an early feature in human idiopathic inflammatory myopathies, also preceding inflammatory infiltrates [ 26].
This dysregulation causes reduced bone mass, which is known to be an early feature in RA patients, visualised as juxta-articular bone demineralisation on radiographs [ 3].
This is consistent with the notion that increased oxidative damage is an early feature in AD development [ 26- 29] and with findings that subsequent increases in Aβ accumulation correlates with the decrease in oxidative stress [ 27, 30].
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