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If transgenerational plasticity or early developmental environment were at least partially responsible for the shifts in plant phenotypes observed across environmental gradients in this experiment, the influence of these factors varied among populations.
Placental mammals are fundamentally different from other mammals in regard to the early developmental environment and fetal nourishment.
The early developmental environment is an influential predictor of subsequent phenotypes and disease risk later in life.
The Home Observation for Measurement of the Environment (HOME) Inventory [ 26, 27] is used to measure the child's early developmental environment in his/her home.
The methylation at differentially methylated region (DMR) of these imprinted genes is established before gastrulation, and is very sensitive to early developmental environment, but can be relatively stable throughout the course of individual's life [ 17, 18].
It is likely that many of the genetic risk factors for depression interact with the early developmental environment, but recapture of these interactions has remained a challenge for aetiological studies of depression.
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In this review, we focus specifically on the relationships between alterations in the early life developmental environment and potential impact on the occurrence of NAFLD.
The early (fetal and neonatal) developmental environment has been proposed as a key sensitive period for increasing susceptibility to adult-onset obesity [2].
When the foetus and infant makes predictive adaptive responses to the environment in the early developmental process, adaptations chosen to cope with the unfavourable environment may have adverse effects for health in later phases of the lifecourse.
This change is worrying, given the many lines of evidence that early life experiences, including the developmental environment, maternal deprivation and human handling, can profoundly alter subsequent morphology, physiology and behaviour [4], [5], [6], [7], [8], [9].
In conclusion, our data provide evidence that exposure to an obesogenic environment during early developmental stages can prime offspring to increased susceptibility to nonalcoholic fatty liver disease.
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