Sentence examples for early compounds from inspiring English sources
Early compounds in the series suffered from poor physicochemical properties and oral bioavailability, and the first two clinical candidates failed in initial human studies.
Early compounds were found to produce liver toxicity, however, and development was discontinued.
However, despite the promising potency of these early compounds, they typically showed high log D values and low stability in microsomes.
Early compounds were based on nitrogen mustards, a powerful class of agents that alkylate bases of DNA (Shore, 1947), leading to cell death.
Early compounds in the pathway are below detection in the Wt and in transgenic lines, with the exception of phytofluene, which shows from moderate to strong increases in both AS-e and AS-h lines.
A number of nonlipid inhibitors were discovered through a screening campaign conducted by French et al. SKI-II is the most well-characterized among this group of early compounds; it is a nonselective SphK inhibitor and has an inhibition constant of 17 μM.
Unlike the compound eyes of modern crustaceans, in these early compound eyes each corneal lens is thought to have served a miniature retina.
In species as different as fruit flies and tadpole shrimps, the stepwise cellular patterning steps of the early compound eye exhibit detailed similarities implying 500 million years of developmental conservation.
This chapter focuses on the recent changes in synthetic chemistry practices, shows how these changes are modulated by the target impact on compound properties, and provides guidance on how the pattern of early compound properties can be improved.
Making the problem more complicated, optics and internal structures of fossil compound eyes are usually difficult if not impossible to work out (with trilobites, as in Fig. 2, being the exception), so reconstructing the operating principles of early compound eyes is rarely practical.
BRD4 occupancy in hESCs was analyzed 6 hr after treatment to identify early compound-responsive elements.
