Sentence examples for early checkpoints from inspiring English sources

· Longer early checkpoints and shorter late checkpoints.

This study suggests that a common feature of mutator polymerases is the impaired recognition of complementary base pairs as "correct", diminishing the overall effectiveness of the early checkpoints.

f We would not necessarily expect the behavior of polymerases at the early checkpoints to account fully for the error specificities reported in Table 6.

Our inference that the early checkpoints are implicated in fidelity is supported by the observation that they are compromised in mutator mutants Y766A and E710A.

As a result, the early checkpoints operate with a lower specificity and a larger proportion of errors pass through the checkpoints.

In WT Pol I KF), the net result of the two early checkpoints is that a ternary complex with a complementary dNTP is uniquely directed to the fully closed complex.

Regular submission: For the students who want to submit the project today, follow the same procedure as for early checkpoint.

We speculate that this module may be an early checkpoint for progression to apoptosis and/or inflammation during macrophage activation.

In the Y766A mutant, the early checkpoint functions normally, but some correctly paired dNTPs do not efficiently undergo fingers closing.

Although the frequency of B cells expressing autoreactive immunoglobulin was lower than during active disease, the data suggest that early checkpoint abnormalities are an integral feature of SLE [ 50].

The loss of these inter-side chain contacts could change the relative stabilities of open, partially closed, and fully closed conformations, influencing the energy profile of the early checkpoint steps.