Biomarkers that can detect AD in its early stages and, importantly, predict future dementia will be invaluable for efficient clinical trial design and eventually patient care.
Fluid and imaging biomarkers of this pathology are currently being sought in order to confirm early diagnoses and, importantly, to identify individuals in the preclinical stage so emerging therapies ultimately have a chance to preserve normal brain function (Craig-Schapiro et al, 2008).
All the major news organizations rued their inability to call results early and, more importantly, explain voters' motivations.
The aim of the present study was to apply 99mTc-MAG3 imaging for longitudinal follow-up studies of early and, most importantly, long-term kidney function after injury.
These results significantly extend earlier results and, importantly, unambiguously place a fully-fledged NPC in LECA.
In part this is because of political correctness and the hegemony of theory that you asked me about earlier, and most importantly, the total concentration of the commercial presses (and many of the so-called non-commercial presses) on sales instead of quality.
In general, cytokine amounts increased earlier and more importantly in arthritic knees than in contralateral saline-injected knees, although some mediators, such as IP-10, IL-12p70, TNFα, or IL-5, failed to be affected significantly by the arthritic process.
These results are consistent with an earlier report [42], and importantly, recapitulate the in vivo requirement of β-catenin phosphorylation.
However, the analysis comparing radiation plus cetuximab to radiation alone resulted in a significant decrease in tumour growth in earlier time points and, importantly, differences were maintained during the follow-up (Supplementary Figure 2).
Using the age of a new lepidosaur fossil from the Middle Triassic of Germany and 13 other fossil constraints, we estimate that Lepidosauria originated between 238 and 249.5 Mya (median age 242) in the Early-Middle Triassic, and importantly that their origin and diversification occurred after the end-Permian mass extinction rather than before it.
