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The "earliest unambiguous instance" of the use of the term for an elevated walkway is in 1356.
The earliest unambiguous detection of M. tuberculosis involves evidence of the disease in the remains of bison in Wyoming dated to around 17,000 years ago.
However, the earliest unambiguous evidence of their use appears in the painting Allegory of Good Government, by Ambrogio Lorenzetti, from 1338.
Instead, the earliest unambiguous fossil described as T. terrestris is dated between 80-88 Ky BP [ 15, 24].
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The earliest known unambiguous examples of written records dating from Egypt and Mesopotamia about 3100 bce demonstrate that ancient peoples had already begun to devise mathematical rules and techniques useful for surveying land areas, constructing buildings, and measuring storage containers.
As alluded to earlier, however, unambiguous assessments of the reward value of alcohol are very difficult to make using operant self-administration or home cage-drinking paradigms.
One passage in Steve Richards' fine book on Brown suggests that, in this case, it may have been the former more than the latter, although it's not totally unambiguous: "Early in 2002 Tony Blair has told the international development secretary, Clare Short, that he would hand over to Brown if the chancellor supported him in a 'yes' campaign for the Euro.
Studies show that a thermogram identifies precancerous or cancerous cells earlier, and produces unambiguous results, which cuts down on additional testing--and it doesn't hurt the body.
This has clinical implications as the CD19+ genes identified could provide robust and biologically meaningful basis for the early detection and unambiguous phenotyping of CFS.
Early identification of unambiguous disease-causing mutations in both NPHS2 alleles could lead to avoidance of prolonged glucocorticoid therapy and perhaps the need for kidney biopsy in these patients.
For mosses, the earliest material that appears unambiguous is from the Permian Period (299 million to 251 million years ago), and the detailed relationships are not clear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com