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Some of the earliest studies identified that mutations in the tumour suppressor gene TP53 were less frequent in LCINS (8 47%) when compared with tobacco smokers with lung cancer (26 71%) [27 29].
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The earliest studies identifying GM1 as the CT receptor were based on inhibition assays and gain-of-function experiments.
The earliest study identified in our search on the use of oral ARV-based technologies for the prevention of sexually transmitted HIV was published in 2008 and reflects the start-point for this review.
The early studies identified only broad peaks [22, 23, 64, 66].
Earlier studies identified a higher sensitivity for the Goldman tool in the ED setting than our results [3, 26].
Early studies identified aberrant DNA methylation, often based on single gene promoter analysis with both biological and clinical impact.
Though a few early studies identified low frequency EP300 mutations in colorectal carcinoma, breast cancer, and gastric cancer, the full spectrum of mutational inactivation of CREBBP and EP300 would not be fully evident until the genomics era.
While early studies identified the functional importance of individual EDC genes, the recognition of the EDC genes as a cluster with its shared biology, homology, and physical linkage was pivotal to later studies that investigated the transcriptional regulation of the locus.
Early studies identified a link between CD40L expression and progression to AIDS [65].
Early studies identified collagen IV in the endotendineum and endomysium of the extensor carpi radialis muscle with attached tendon [21].
Early studies identified the presence or absence of the 3' poly A tail on transcripts, resulting in their classification as either poly A+ transcripts or poly A- transcripts [1] [11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com