It is therefore essential to have accurate and reliable measurement of renal function and early specific markers of renal impairment in patients with HF.
Taken together, these results point to the possibility that immunodetection of the 85 90 kDa palladin isoform in samples collected by EUS-guided fine-needle aspiration may have diagnostic utility as an early, specific marker for the development of pancreatic adenocarcinoma, which may provide new avenues for diagnosing pancreatic cancer at a treatable stage of the disease.
mpo was also the earliest specific myeloid marker after spib.
Using double in situ hybridisation, Xfzd7 expression showed overlapping with that of early heart specific markers including XNkx2.5, XTroponin-1C, Gata4, Gata5 and Gata6.
High lactate and the lactate-to-pyruvate ratio or glycerol release to the bowel lumen are considered as early and specific markers of the damage of the gut epithelial cells [ 8, 9, 12, 14].
Furthermore, in the analysis of the inflammatory response we did not include mRNA expression of cytokines or myeloperoxidase activity which may have been earlier and specific markers to evaluate the inflammatory response, especially due to the short period spent on mechanical ventilation.
Consistent with our results, RT PCR detected expression of proteoglycan core proteins in both undifferentiated cells and in those expressing Sox1 (the earliest known specific marker of neuroectodermal precursors, before their differentiation into neurons and glia).
Indeed, we found a significant upregulation of DNA-PKcs and of its target H2AX, an earliest and specific marker of DSB (Garcia-Canton et al, 2012), in HCC when compared with normal livers and non-tumourous surrounding livers.
In each case, there is specificity: specific markers, specific genes, specific molecules specific antibodies, specific targets.
Clinically, it is desirable to rely on an early and specific marker for final neurological outcome.
