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While Nasa's latest rover Curiosity is looking at the oldest rock formations, we want to look at signs that tell us about the earliest processes of Mars.
"Our mutations affect some of the very earliest processes in development," says Nüsslein-Volhard. "We hope this will open up new areas of research".
We have recently demonstrated that the pool of sulfated polysaccharides from L. saccharina efficiently blocks the adhesion of a highly metastatic tumor cell line to human platelets [2], suggesting that this compound could also be a promising inhibitor of one of the earliest processes favouring tumor metastasis [22].
Kohjimoto et al. reported that crystal-cell interactions may be among the earliest processes in the formation of kidney stones [ 39].
Questions such as 'which are the earliest processes taking place in the pathogenesis of arthritis?' and 'which cells are most important in the disease process at which stage?' might become answered by live-animal imaging with specific probes.
Importantly, since gait changes are detectable already before the onset of clinically visible symptoms of arthritis such as erythema and swelling, automated locomotor analysis may be of particular interest to define the earliest processes involved in a very severe and debilitating disease such as PIA.
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He experimented with earlier processes which were able to capture images but would subsequently fade in order to create an effective method of producing permanent images.
Recently, our understanding of early processes underlying salinity tolerance has expanded.
The unique property of bone to regenerate is highly dependent of these early processes during healing (Harty et al. 2003).
This paper is concerned with the early processes of design, particularly in the context of spatial arrangements.
That era "heralded an age of exchange, conquest, coercive trading and colonialism, animating the early processes of globalization".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com