Sentence examples for earliest mutations have from inspiring English sources

On the contrary, it is very likely that the evolutionary trajectories of paralogs are altered at birth or in evolutionary infancy given the possibility that the earliest mutations have a disproportionately larger effect in dictating divergent evolutionary trajectories for paralogs.

In contrast, in the fast scenario, extent of expansion should increase rapidly early in life, up to the point when the earliest mutations had enough time to expand to the limits of their host cells and increase much slower thereafter.

Thus, early genome-destabilizing mutations have the potential to shape the evolutionary trajectory of precancerous cells and intratumoral heterogeneity in large tumor cell populations.

BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain.

Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers.

Notably, disease severity correlated with position of mutation (Fig.  4), with two "early" truncating mutations having the most severe phenotype with SCID, while the combination of an "early" truncating mutation with the c.2440C>T (p.Arg814*) mutation led to global growth reduction without clinically apparent immunodeficiency before investigation.

EGFR mutations have earlier been identified as one of the key mutations affecting lung adenocarcinoma patients in a comprehensive study of 188 patients [39].

For the green subclone, some point mutations (e.g., SEMA3E and ASXL1) are seen already at this early point, but most mutations have substantial uncertainty associated with them.

One caveat of our system is that BRAFV600E could play a role in inducing DNA methylation only early in colorectal tumorigenesis, as BRAF mutations have been described at the earliest stage of tumor development [10], [38], [39].

As mentioned earlier, almost 2000 individual CFTR mutations have been identified, and particular challenges exist around developing therapeutic strategies for CFTR mutations that are individually very rare.

In the example given earlier, a number of different mutations have affected the same gene in multiple different species (eg, KIT and MC1R).