Dorset has been forced to go back to the drawing board after an earlier large scale consultation failed to find a suitable site.
Earlier, large scale sequencing studies were limited to the identification of only conserved miRNAs in potato [ 27].
Sankin et al. reported an increased mutation frequency in intratumour multiregion analysis, compared to earlier large scale sequencing studies [ 96].
The degree to which such variants contribute to Crohn's disease heritability is unclear, and the results from early large scale sequencing studies targeted at known susceptibility genes have been disappointing [81,91,92].
These strategies appeared to have had only limited success, with the notable exception of Japan where early, large scale closure of schools suppressed an outbreak that was spreading rapidly amongst school-aged children [ 43].
The early large scale transcriptional profiling efforts provided the initial impetus for characterizing the phenotypic heterogeneity of cancer that allowed to discover transcriptionally-uniform cancer subtypes that were associated with distinct clinical outcomes [ 7, 8].
The Smithsonian American Art Museum has acquired a collection of artwork and research materials from the artists Christo and Jeanne-Claude that document "Running Fence," one of their earliest large-scale installations.
So, for sleaze appeal, they added a blue banner high up on the cover promising the low-down on "Sinatra and His 'Rat Pack.' " These are the earliest large-scale Warhol paintings to use existing tabloid headlines as a subject, and the last on the theme that he would do in a brushy, painterly style.
The theatre, designed by Giovanni Battista Aleotti and built in 1618 (but not used until 1628, to celebrate the marriage of a Medici daughter to a Farnese son), was the first proscenium theatre to be designed for movable scenery and is the earliest large-scale indoor theatrical facility to have survived.
They are the earliest large-scale seed remains found in Taiwan up to now.
