Subjects who qualified as initiators of more than one study drug entered the cohort of the earliest initiated study drug.
Our data suggest that epigenetic repression of p16 by BMI-1 may also be an early initiating event in EWS-FLI1-induced malignant transformation.
The possibility that aneuploidy may occur as an early, initiating event and thus a driving force of tumorigenesis has been argued from the perspective of a mathematical genetic model [35].
In addition, to our knowledge this is the first demonstration that EWS-FLI1-mediated induction of BMI-1 and epigenetic silencing of p16 might be critical early initiating events in ESFT tumorigenesis.
PET amyloid imaging studies in patients with mild cognitive impairment and mild AD have demonstrated that the deposition of fibrillar Aβ is one of the early initiating pathogenic events in the disease process [35].
Prostaglandins are biosynthesized early, initiating the acute inflammatory response.
Such poor self-rated health persisted even after smoking cessation among early initiating boys.
Such poor self-rated health persisted also after smoking cessation among early initiating boys.
Poorer self-rated health persisted also after smoking cessation among early initiating boys.
In early skin cancer development, a single p53 allele is mutated or deleted as an early initiating oncogenic event.
Together these results support the possibility that the contractile dysfunction is an early initiating event in HCM disease pathogenesis.
