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Their frequence was 22% in the earliest head and neck premalignant lesions and increased with the degree of dysplasia to reach 50% in lesions of severe dysplasia and 61% in carcinomas in situ in a recent study (Ha et al, 2002).
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Fortin et al (2002) concluded that delaying radiotherapy had a deleterious effect on patients with early head-and-neck squamous cell carcinomas.
However, evidence linking early nutritional intervention with improved early head (and then ultimately neurodevelopmental outcome) is still lacking.
However, in a previous clinical trial, chemoprevention therapy involving retinoid acid does not cause significant differences in early head and neck cancers.
They appear to prefer those hanfets in which both components are early heading and maturing.
Norin 1 was a mainstay cultivar in the Hokuriku region at that time owing to its early heading and high yield.
For DTH2, both association analysis and transgenic experiments indicate that two functional nucleotide polymorphisms that correlated with early heading and increased reproductive fitness under natural LD in northern Asia.
This indicates that early heading and weak or absent photoperiod sensitivity are essential for rice cultivars to be able to adapt to the climate changes that occur in northern areas of China and Japan.
Meanwhile, Ishikawa et al. (2012) proposed that lcd-kmt1 and lcd-kmt2 were more promising for breeding program according to agronomic traits, as a consequence of earlier heading and smaller plant size than Koshihikari WT in lcd-kmt3 (Ishikawa et al. 2012).
Red and blue characters indicate early heading and late heading alleles, respectively.
Moreover, genotypes with the Hap-6A-A allele had earlier heading and maturity dates of about 3.5 and 2.5 days than Hap-6A-G genotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com