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Alternatively, the HN-like changes could reflect breast cancer's earliest gene expression changes.
To this end we have studied the earliest gene expression changes that could be associated with the synaptic phenotype.
If this were true, then the expression changes would not be an effect of the tumour, but instead may be a marker of increased breast cancer risk, or an indication of breast cancer's earliest gene expression changes.
This suggests that the HN profile is not an effect of the tumour, but instead may be a marker of increased breast cancer risk, or a reflection of breast cancer's earliest gene expression changes.
The earliest gene expression change along the growth curve was evidenced by a cluster of genes that are mainly involved in nitrogen metabolism, including glutamine synthetase I and II, and the signaling protein glnK: it starts off at high expression at the earliest time points (20 h after inoculation = very early exponential phase).
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However, IE180 encoding the immediate early protein IEP, a transactivator of early gene expression was found differentially expressed at 4 h pi.
Previous studies also assessed the effects of repeated methylphenidate treatment on immediate-early gene expression.
Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression.
Enkephalin regulates acute D2 dopamine receptor antagonist-induced immediate-early gene expression in striatal neurons.
Effects of phencyclidine on immediate early gene expression in the brain.
Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine.
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